Age-Dependent Shift of AMPA Receptors From Synapses to Intracellular Compartments in Alzheimer’s Disease: Immunocytochemical Analysis of the CA1 Hippocampal Region in APP/PS1 Transgenic Mouse Model

Synapse loss occurs early in Alzheimer’s disease (AD) patients and animal models. Alterations at synaptic level are a major morphological correlate of the memory deficits and related symptoms of AD. Given the predominant roles of synaptic AMPA receptors (AMPARs) in excitatory synaptic transmission i...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Martín-Belmonte, Alejandro, Aguado, Carolina, Alfaro-Ruíz, Rocío, Itakura, Makoto, Moreno-Martínez, Ana Esther, de la Ossa, Luis, Molnár, Elek, Fukazawa, Yugo, Luján, Rafael
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572859/
https://ncbi.nlm.nih.gov/pubmed/33132900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2020.577996
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