Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix

Light-activated protein domains provide a convenient, modular, and genetically encodable sensor for optogenetics and optobiology. Although these domains have now been deployed in numerous systems, the precise mechanism of photoactivation and the accompanying structural dynamics that modulate output...

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Publicado en:ACS Chem Biol
Main Authors: Iuliano, James N., Collado, Jinnette Tolentino, Gil, Agnieszka A., Ravindran, Pavithran T., Lukacs, Andras, Shin, SeungYoun, Woroniecka, Helena A., Adamczyk, Katrin, Aramini, James M., Edupuganti, Uthama R., Hall, Christopher R., Greetham, Gregory M., Sazanovich, Igor V., Clark, Ian P., Daryaee, Taraneh, Toettcher, Jared E., French, Jarrod B., Gardner, Kevin H., Simmerling, Carlos L., Meech, Stephen R., Tonge, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572778/
https://ncbi.nlm.nih.gov/pubmed/32880430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00543
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