Lung atelectasis promotes immune and barrier dysfunction as revealed by transcriptome sequencing in female sheep

BACKGROUND: Pulmonary atelectasis is frequent in clinical settings. Yet, there is limited mechanistic understanding and substantial clinical and biological controversy on its consequences. We hypothesize that atelectasis produces local transcriptomic changes related to immunity and alveolar-capillar...

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Veröffentlicht in:Anesthesiology
Hauptverfasser: Zeng, Congli, Motta-Ribeiro, Gabriel C., Hinoshita, Takuga, Lessa, Marcos Adriano, Winkler, Tilo, Grogg, Kira, Kingston, Nathan M, Hutchinson, John N., Sholl, Lynette Marie, Fang, Xiangming, Varelas, Xaralabos, Layne, Matthew D., Baron, Rebecca M., Vidal Melo, Marcos F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572680/
https://ncbi.nlm.nih.gov/pubmed/32796202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000003491
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