PD-L1 protein expression on both tumor cells and macrophages are associated with response to neoadjuvant durvalumab with chemotherapy in triple negative breast cancer (TNBC)

BACKGROUND: In both the IMpassion 130 trial in the metastatic setting and in Keynote 522 in the neoadjuvant setting, triple negative breast cancer (TNBC) patients showed benefit from PD-1 axis immunotherapy. Here, we assess PD-L1 expression on both tumor and immune cells using quantitative immunoflu...

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Udgivet i:Clin Cancer Res
Main Authors: Ahmed, Fahad Shabbir, Gaule, Patricia, McGuire, John, Patel, Katir, Blenman, Kim, Pusztai, Lajos, Rimm, David L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572612/
https://ncbi.nlm.nih.gov/pubmed/32709714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-1303
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