The expression of YAP1 is increased in high-grade prostatic adenocarcinoma but is reduced in neuroendocrine prostate cancer

BACKGROUND: After long-term androgen deprivation therapy, 25–30% prostate cancer (PCa) acquires an aggressive neuroendocrine (NE) phenotype. Dysregulation of YAP1, a key transcription coactivator of the Hippo pathway, has been related to cancer progression. However, its role in neuroendocrine prosta...

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Detalhes bibliográficos
Publicado no:Prostate Cancer Prostatic Dis
Main Authors: Cheng, Siyuan, Prieto-Dominguez, Nestor, Yang, Shu, Connelly, Zachary M., StPierre, Samantha, Rushing, Bryce, Watkins, Andy, Shi, Lawrence, Lakey, Meredith, Baiamonte, Lyndsey Buckner, Fazili, Tajammul, Lurie, Aubrey, Corey, Eva, Shi, Runhua, Yeh, Yunshin, Yu, Xiuping
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572469/
https://ncbi.nlm.nih.gov/pubmed/32313141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41391-020-0229-z
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