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A hypothesis for pathobiology and treatment of COVID‐19: The centrality of ACE1/ACE2 imbalance

Angiotensin Converting Enzyme2 is the cell surface binding site for the coronavirus SARS‐CoV‐2, which causes COVID‐19. We propose that an imbalance in the action of ACE1‐ and ACE2‐derived peptides, thereby enhancing angiotensin II (Ang II) signalling is primary driver of COVID‐19 pathobiology. ACE1/...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Sriram, Krishna, Insel, Paul A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572451/
https://ncbi.nlm.nih.gov/pubmed/32333398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.15082
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