KRAS(G12C) Inhibition with Sotorasib in Advanced Solid Tumors

BACKGROUND: No therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non–small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal cancers and other cancers. Sotorasib is a small molecule that selectively and irreversibly targets KRAS(G12C...

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Veröffentlicht in:N Engl J Med
Hauptverfasser: Hong, D.S., Fakih, M.G., Strickler, J.H., Desai, J., Durm, G.A., Shapiro, G.I., Falchook, G.S., Price, T.J., Sacher, A., Denlinger, C.S., Bang, Y.-J., Dy, G.K., Krauss, J.C., Kuboki, Y., Kuo, J.C., Coveler, A.L., Park, K., Kim, T.W., Barlesi, F., Munster, P.N., Ramalingam, S.S., Burns, T.F., Meric-Bernstam, F., Henary, H., Ngang, J., Ngarmchamnanrith, G., Kim, J., Houk, B.E., Canon, J., Lipford, J.R., Friberg, G., Lito, P., Govindan, R., Li, B.T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571518/
https://ncbi.nlm.nih.gov/pubmed/32955176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1917239
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