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Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to
The fusion oncoprotein Bcr-Abl is an aberrant tyrosine kinase responsible for chronic myeloid leukemia and acute lymphoblastic leukemia. The auto-inhibition regulatory module observed in the progenitor kinase c-Abl is lost in the aberrant Bcr-Abl, because of the lack of the N-myristoylated cap able...
Shranjeno v:
| izdano v: | Molecules |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
MDPI
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7570842/ https://ncbi.nlm.nih.gov/pubmed/32937901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25184210 |
| Oznake: |
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