Establishment of a Controlled Human Infection Model with a Lyophilized Strain of Shigella sonnei 53G

Controlled human infection models (CHIMs) are useful for vaccine development. To improve on existing models, we developed a CHIM using a lyophilized preparation of Shigella sonnei strain 53G produced using current good manufacturing practice (cGMP). Healthy adults were enrolled in an open-label dose...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: Frenck, Robert W., Dickey, Michelle, Suvarnapunya, Akamol E., Chandrasekaran, Lakshmi, Kaminski, Robert W., Clarkson, Kristen A., McNeal, Monica, Lynen, Amanda, Parker, Susan, Hoeper, Amy, Mani, Sachin, Fix, Alan, Maier, Nicole, Venkatesan, Malabi M., Porter, Chad K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568646/
https://ncbi.nlm.nih.gov/pubmed/32968005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00416-20
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