ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo

Signs of proteostasis failure often entwine with those of metabolic stress at the cellular level. Here, we study protein sequestration during glucose deprivation-induced ATP decline in Saccharomyces cerevisiae. Using live-cell imaging, we find that sequestration of misfolded proteins and nascent pol...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Sathyanarayanan, Udhayabhaskar, Musa, Marina, Bou Dib, Peter, Raimundo, Nuno, Milosevic, Ira, Krisko, Anita
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568574/
https://ncbi.nlm.nih.gov/pubmed/33067463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19104-1
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