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ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo

Signs of proteostasis failure often entwine with those of metabolic stress at the cellular level. Here, we study protein sequestration during glucose deprivation-induced ATP decline in Saccharomyces cerevisiae. Using live-cell imaging, we find that sequestration of misfolded proteins and nascent pol...

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Bibliografische gegevens
Gepubliceerd in:Nat Commun
Hoofdauteurs: Sathyanarayanan, Udhayabhaskar, Musa, Marina, Bou Dib, Peter, Raimundo, Nuno, Milosevic, Ira, Krisko, Anita
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568574/
https://ncbi.nlm.nih.gov/pubmed/33067463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19104-1
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