Activation of SIRT1/PGC 1α/SIRT3 pathway by melatonin provides protection against mitochondrial dysfunction in isoproterenol induced myocardial injury

AIMS: Preventing mitochondrial dysfunction and enhancing mitochondrial health and biogenesis is a crucial therapeutic approach to ameliorate injury following acute myocardial infarction. Although the antioxidant role of melatonin against ischemia/reperfusion injury has been reported, the exact mecha...

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Bibliographic Details
Published in:Heliyon
Main Authors: Naaz, Shamreen, Mishra, Sanatan, Pal, Palash K., Chattopadhyay, Aindrila, Das, Asish R., Bandyopadhyay, Debasish
Format: Artigo
Language:Inglês
Published: Elsevier 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567935/
https://ncbi.nlm.nih.gov/pubmed/33088945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2020.e05159
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