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Higher cytolytic score correlates with an immunosuppressive tumor microenvironment and reduced survival in glioblastoma
Cytolytic score (CYT), calculated from mRNA expression levels of granzyme and perforin, positively correlates with CD8+ T cell infiltration/activity in a variety of cancers. Unlike other cancers, higher CYT has been associated with worse prognosis in glioblastoma (GBM). To address this discrepancy,...
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| Veröffentlicht in: | Sci Rep |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7567862/ https://ncbi.nlm.nih.gov/pubmed/33067480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73793-8 |
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