Exploiting oxidative phosphorylation to promote the stem and immunoevasive properties of pancreatic cancer stem cells

Pancreatic ductal adenocarcinoma (PDAC), the fourth leading cause of cancer death, has a 5-year survival rate of approximately 7–9%. The ineffectiveness of anti-PDAC therapies is believed to be due to the existence of a subpopulation of tumor cells known as cancer stem cells (CSCs), which are functi...

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Published in:Nat Commun
Main Authors: Valle, Sandra, Alcalá, Sonia, Martin-Hijano, Laura, Cabezas-Sáinz, Pablo, Navarro, Diego, Muñoz, Edurne Ramos, Yuste, Lourdes, Tiwary, Kanishka, Walter, Karolin, Ruiz-Cañas, Laura, Alonso-Nocelo, Marta, Rubiolo, Juan A., González-Arnay, Emilio, Heeschen, Christopher, Garcia-Bermejo, Laura, Hermann, Patrick C., Sánchez, Laura, Sancho, Patricia, Fernández-Moreno, Miguel Ángel, Sainz, Bruno
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567808/
https://ncbi.nlm.nih.gov/pubmed/33067432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18954-z
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