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GPAHex-A synthetic biology platform for Type IV–V glycopeptide antibiotic production and discovery

Glycopeptide antibiotics (GPAs) are essential for the treatment of severe infectious diseases caused by Gram-positive bacteria. The emergence and spread of GPA resistance have propelled the search for more effective GPAs. Given their structural complexity, genetic intractability, and low titer, expa...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Xu, Min, Wang, Wenliang, Waglechner, Nicholas, Culp, Elizabeth J., Guitor, Allison K., Wright, Gerard D.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567792/
https://ncbi.nlm.nih.gov/pubmed/33067466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19138-5
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