Generation of desminopathy in rats using CRISPR‐Cas9

BACKGROUND: Desminopathy is a clinically heterogeneous muscle disease caused by over 60 different mutations in desmin. The most common mutation with a clinical phenotype in humans is an exchange of arginine to proline at position 350 of desmin leading to p.R350P. We created the first CRISPR‐Cas9 eng...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:J Cachexia Sarcopenia Muscle
Autori principali: Langer, Henning T., Mossakowski, Agata A., Willis, Brandon J., Grimsrud, Kristin N., Wood, Joshua A., Lloyd, Kevin C.K., Zbinden‐Foncea, Hermann, Baar, Keith
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567154/
https://ncbi.nlm.nih.gov/pubmed/32893996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcsm.12619
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi