Activation of CD8 T cells accelerates anti-PD-1 antibody-induced psoriasis-like dermatitis through IL-6

Use of immune checkpoint inhibitors that target programmed cell death-1 (PD-1) can lead to various autoimmune-related adverse events (irAEs) including psoriasis-like dermatitis. Our observations on human samples indicated enhanced epidermal infiltration of CD8 T cells, and the pathogenesis of which...

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Gepubliceerd in:Commun Biol
Hoofdauteurs: Tanaka, Ryota, Ichimura, Yuki, Kubota, Noriko, Saito, Akimasa, Nakamura, Yoshiyuki, Ishitsuka, Yosuke, Watanabe, Rei, Fujisawa, Yasuhiro, Kanzaki, Mirei, Mizuno, Seiya, Takahashi, Satoru, Fujimoto, Manabu, Okiyama, Naoko
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567105/
https://ncbi.nlm.nih.gov/pubmed/33060784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01308-2
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