Solving an MHC allele–specific bias in the reported immunopeptidome

Identification of MHC class I–bound peptides by immunopurification of MHC complexes and subsequent analysis by mass spectrometry is crucial for understanding T cell immunology and immunotherapy. Investigation of the steps for the MHC ligand isolation process revealed biases in widely used isolation...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Klatt, Martin G., Mack, Kyeara N., Bai, Yang, Aretz, Zita E. H., Nathan, Levy I., Mun, Sung Soo, Dao, Tao, Scheinberg, David A.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2020
Subjects:
Technical Advance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566711/
https://ncbi.nlm.nih.gov/pubmed/32897882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.141264
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