Fibroblast growth factor homologous factors tune arrhythmogenic late Na(V)1.5 current in calmodulin binding–deficient channels

The Ca(2+)-binding protein calmodulin has emerged as a pivotal player in tuning Na(+) channel function, although its impact in vivo remains to be resolved. Here, we identify the role of calmodulin and the Na(V)1.5 interactome in regulating late Na(+) current in cardiomyocytes. We created transgenic...

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Pubblicato in:JCI Insight
Autori principali: Abrams, Jeffrey, Roybal, Daniel, Chakouri, Nourdine, Katchman, Alexander N., Weinberg, Richard, Yang, Lin, Chen, Bi-xing, Zakharov, Sergey I., Hennessey, Jessica A., Avula, Uma Mahesh R., Diaz, Johanna, Wang, Chaojian, Wan, Elaine Y., Pitt, Geoffrey S., Ben-Johny, Manu, Marx, Steven O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566708/
https://ncbi.nlm.nih.gov/pubmed/32870823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.141736
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