Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease

The emergence of SARS-CoV-2 has created an international health crisis, and small animal models mirroring SARS-CoV-2 human disease are essential for medical countermeasure (MCM) development. Mice are refractory to SARS-CoV-2 infection owing to low-affinity binding to the murine angiotensin-convertin...

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Udgivet i:JCI Insight
Main Authors: Golden, Joseph W., Cline, Curtis R., Zeng, Xiankun, Garrison, Aura R., Carey, Brian D., Mucker, Eric M., White, Lauren E., Shamblin, Joshua D., Brocato, Rebecca L., Liu, Jun, Babka, April M., Rauch, Hypaitia B., Smith, Jeffrey M., Hollidge, Bradley S., Fitzpatrick, Collin, Badger, Catherine V., Hooper, Jay W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566707/
https://ncbi.nlm.nih.gov/pubmed/32841215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.142032
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