Nna1 gene deficiency triggers Purkinje neuron death by tubulin hyperglutamylation and ER dysfunction

Posttranslational glutamylation/deglutamylation balance in tubulins influences dendritic maturation and neuronal survival of cerebellar Purkinje neurons (PNs). PNs and some additional neuronal types degenerate in several spontaneous, independently occurring Purkinje cell degeneration (pcd) mice feat...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Li, Jianxue, Snyder, Evan Y., Tang, Fenny H.F., Pasqualini, Renata, Arap, Wadih, Sidman, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566705/
https://ncbi.nlm.nih.gov/pubmed/33004692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.136078
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