Caveolin-1-Mediated Tumor Suppression Is Linked to Reduced HIF1α S-Nitrosylation and Transcriptional Activity in Hypoxia

Caveolin-1 (CAV1) is a well-established nitric oxide synthase inhibitor, whose function as a tumor suppressor is favored by, but not entirely dependent on, the presence of E-cadherin. Tumors are frequently hypoxic and the activation of the hypoxia-inducible factor-1α (HIF1α) promotes tumor growth. H...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Sanhueza, Carlos, Bennett, Jimena Castillo, Valenzuela-Valderrama, Manuel, Contreras, Pamela, Lobos-González, Lorena, Campos, América, Wehinger, Sergio, Lladser, Álvaro, Kiessling, Rolf, Leyton, Lisette, Quest, Andrew F.G.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565942/
https://ncbi.nlm.nih.gov/pubmed/32825247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12092349
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