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Histidine Residues Are Responsible for Bidirectional Effects of Zinc on Acid-Sensing Ion Channel 1a/3 Heteromeric Channels

Acid-sensing ion channel (ASIC) subunits 1a and 3 are highly expressed in central and peripheral sensory neurons, respectively. Endogenous biomolecule zinc plays a critical role in physiological and pathophysiological conditions. Here, we found that currents recorded from heterologously expressed AS...

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Bibliografiske detaljer
Udgivet i:Biomolecules
Main Authors: Jiang, Qian, Peterson, Andrew M., Chu, Yuyang, Yao, Xiaolan, Zha, Xiang-ming, Chu, Xiang-Ping
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565092/
https://ncbi.nlm.nih.gov/pubmed/32887365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10091264
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