DJ-1 Proteoforms in Breast Cancer Cells: The Escape of Metabolic Epigenetic Misregulation

Enhanced glycolysis is a hallmark of breast cancer. In cancer cells, the high glycolytic flux induces carbonyl stress, a damaging condition in which the increase of reactive carbonyl species makes DNA, proteins, and lipids more susceptible to glycation. Together with glucose, methylglyoxal (MGO), a...

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Bibliographic Details
Published in:Cells
Main Authors: Scumaci, Domenica, Olivo, Erika, Fiumara, Claudia Vincenza, La Chimia, Marina, De Angelis, Maria Teresa, Mauro, Sabrina, Costa, Giosuè, Ambrosio, Francesca Alessandra, Alcaro, Stefano, Agosti, Valter, Costanzo, Francesco Saverio, Cuda, Giovanni
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7563694/
https://ncbi.nlm.nih.gov/pubmed/32858971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9091968
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