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Phosphatidylethanolamine-phosphatidylserine binding synergy of seven coagulation factors revealed using Nanodisc arrays on silicon photonic sensors

Blood coagulation is regulated through protein–protein and protein–lipid interactions that occur at the sub-endothelium following vascular damage. Soluble clotting proteins bind to membrane components in a phosphatidylserine (PS) dependent manner to assemble multi-protein complexes that regulate clo...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Medfisch, Sara M., Muehl, Ellen M., Morrissey, James H., Bailey, Ryan C.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7562748/
https://ncbi.nlm.nih.gov/pubmed/33060620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73647-3
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