Combination efficacy of pertuzumab and trastuzumab for trastuzumab emtansine-resistant cells exhibiting attenuated lysosomal trafficking or efflux pumps upregulation

PURPOSE: Trastuzumab emtansine (T-DM1) is the standard treatment in the current second-line therapy of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. However, a useful therapy after T-DM1 resistance has not been established. In this study, we established two diffe...

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Udgivet i:Cancer Chemother Pharmacol
Main Authors: Yamashita-Kashima, Yoriko, Shu, Sei, Osada, Masahiro, Fujimura, Takaaki, Yoshiura, Shigeki, Harada, Naoki, Yoshimura, Yasushi
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561595/
https://ncbi.nlm.nih.gov/pubmed/32997196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-020-04138-5
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