Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients

In ovarian cancer (OC), IL-17-producing T cells (Th17s) predict improved survival, whereas regulatory T cells predict poorer survival. We previously developed a vaccine whereby patient-derived dendritic cells (DCs) are programmed to induce Th17 responses to the OC antigen folate receptor alpha (FRα)...

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Udgivet i:Nat Commun
Main Authors: Block, Matthew S., Dietz, Allan B., Gustafson, Michael P., Kalli, Kimberly R., Erskine, Courtney L., Youssef, Bahaaeldin, Vijay, Geraldine V., Allred, Jacob B., Pavelko, Kevin D., Strausbauch, Michael A., Lin, Yi, Grudem, Megan E., Jatoi, Aminah, Klampe, Carolyn M., Wahner-Hendrickson, Andrea E., Weroha, S. John, Glaser, Gretchen E., Kumar, Amanika, Langstraat, Carrie L., Solseth, Mary L., Deeds, Michael C., Knutson, Keith L., Cannon, Martin J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560895/
https://ncbi.nlm.nih.gov/pubmed/33057068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18962-z
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