Galunisertib Drives Treg Fragility and Promotes Dendritic Cell-Mediated Immunity against Experimental Lymphoma

Galunisertib (LY2157299) is a selective ATP-mimetic inhibitor of TGF-β receptor-I activation, currently under clinical trial in a variety of cancers. We have tested the combined effects of galunisertib- and interleukin-15-activated dendritic cells in an aggressive and highly metastatic murine lympho...

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Gepubliceerd in:iScience
Hoofdauteurs: Hira, Sumit Kumar, Rej, Abhinandan, Paladhi, Ankush, Singh, Ranjeet, Saha, Jayasree, Mondal, Indrani, Bhattacharyya, Sankar, Manna, Partha Pratim
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7559877/
https://ncbi.nlm.nih.gov/pubmed/33089111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101623
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