Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice

Non-invasive brain delivery of neurotherapeutics is challenging due to the blood-brain barrier. The revived interest in transferrin receptor antibodies (TfRMAbs) as brain drug-delivery vectors has revealed the effect of dosing regimen, valency, and affinity on brain uptake, TfR expression, and Fc-ef...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics
Main Authors: Castellanos, Demi M., Sun, Jiahong, Yang, Joshua, Ou, Weijun, Zambon, Alexander C., Pardridge, William M., Sumbria, Rachita K.
Format: Artigo
Language:Inglês
Published: MDPI 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7558337/
https://ncbi.nlm.nih.gov/pubmed/32911688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12090852
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items