L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson’s Disease by Regulating Glutamine Metabolism

Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and involves deficiencies in alpha-synuclein (α-Syn) degradation. Effective therapeutic strategies for PD are urgently needed. L-asparaginase (L-ASNase) has been developed for therapeutic applications...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Zhang, Qingxi, Gao, Yuyuan, Zhang, Jiahui, Li, You, Chen, Jianing, Huang, Rui, Ma, Guixian, Wang, Limin, Zhang, Yuhu, Nie, Kun, Wang, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557534/
https://ncbi.nlm.nih.gov/pubmed/33117129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.563054
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