Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction

AIMS: Endothelin-1 (ET-1) is a potent vasoconstrictor peptide linked to vascular diseases through a common intronic gene enhancer [(rs9349379-G allele), chromosome 6 (PHACTR1/EDN1)]. We performed a multimodality investigation into the role of ET-1 and this gene variant in the pathogenesis of coronar...

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Bibliografiset tiedot
Julkaisussa:Eur Heart J
Päätekijät: Ford, Thomas J, Corcoran, David, Padmanabhan, Sandosh, Aman, Alisha, Rocchiccioli, Paul, Good, Richard, McEntegart, Margaret, Maguire, Janet J, Watkins, Stuart, Eteiba, Hany, Shaukat, Aadil, Lindsay, Mitchell, Robertson, Keith, Hood, Stuart, McGeoch, Ross, McDade, Robert, Yii, Eric, Sattar, Naveed, Hsu, Li-Yueh, Arai, Andrew E, Oldroyd, Keith G, Touyz, Rhian M, Davenport, Anthony P, Berry, Colin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2020
Aiheet:
Clinical Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557475/
https://ncbi.nlm.nih.gov/pubmed/31972008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehz915
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