Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction

AIMS: Endothelin-1 (ET-1) is a potent vasoconstrictor peptide linked to vascular diseases through a common intronic gene enhancer [(rs9349379-G allele), chromosome 6 (PHACTR1/EDN1)]. We performed a multimodality investigation into the role of ET-1 and this gene variant in the pathogenesis of coronar...

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Udgivet i:Eur Heart J
Main Authors: Ford, Thomas J, Corcoran, David, Padmanabhan, Sandosh, Aman, Alisha, Rocchiccioli, Paul, Good, Richard, McEntegart, Margaret, Maguire, Janet J, Watkins, Stuart, Eteiba, Hany, Shaukat, Aadil, Lindsay, Mitchell, Robertson, Keith, Hood, Stuart, McGeoch, Ross, McDade, Robert, Yii, Eric, Sattar, Naveed, Hsu, Li-Yueh, Arai, Andrew E, Oldroyd, Keith G, Touyz, Rhian M, Davenport, Anthony P, Berry, Colin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Clinical Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557475/
https://ncbi.nlm.nih.gov/pubmed/31972008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehz915
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