Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction

AIMS: Endothelin-1 (ET-1) is a potent vasoconstrictor peptide linked to vascular diseases through a common intronic gene enhancer [(rs9349379-G allele), chromosome 6 (PHACTR1/EDN1)]. We performed a multimodality investigation into the role of ET-1 and this gene variant in the pathogenesis of coronar...

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Bibliografske podrobnosti
izdano v:Eur Heart J
Main Authors: Ford, Thomas J, Corcoran, David, Padmanabhan, Sandosh, Aman, Alisha, Rocchiccioli, Paul, Good, Richard, McEntegart, Margaret, Maguire, Janet J, Watkins, Stuart, Eteiba, Hany, Shaukat, Aadil, Lindsay, Mitchell, Robertson, Keith, Hood, Stuart, McGeoch, Ross, McDade, Robert, Yii, Eric, Sattar, Naveed, Hsu, Li-Yueh, Arai, Andrew E, Oldroyd, Keith G, Touyz, Rhian M, Davenport, Anthony P, Berry, Colin
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2020
Teme:
Clinical Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7557475/
https://ncbi.nlm.nih.gov/pubmed/31972008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehz915
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