LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose

BACKGROUND: Understanding the pathophysiology of the blood brain–barrier (BBB) plays a critical role in diagnosis and treatment of disease conditions. Applying a sensitive and specific LC–MS/MS technique for the measurement of BBB integrity with high precision, we have recently introduced non-radioa...

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Detalhes bibliográficos
Publicado no:Fluids Barriers CNS
Main Authors: Noorani, Behnam, Chowdhury, Ekram Ahmed, Alqahtani, Faleh, Ahn, Yeseul, Patel, Dhavalkumar, Al-Ahmad, Abraham, Mehvar, Reza, Bickel, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556948/
https://ncbi.nlm.nih.gov/pubmed/33054801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12987-020-00224-1
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