An NF-κB–driven lncRNA orchestrates colitis and circadian clock

We uncover a cycling and NF-κB–driven lncRNA (named Lnc-UC) that epigenetically modifies transcription of circadian clock gene Rev-erbα, thereby linking circadian clock to colitis. Cycling expression of Lnc-UC is generated by the central clock protein Bmal1 via an E-box element. NF-κB activation in...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Adv
Prif Awduron: Wang, Shuai, Lin, Yanke, Li, Feng, Qin, Zifei, Zhou, Ziyue, Gao, Lu, Yang, Zemin, Wang, Zhigang, Wu, Baojian
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Association for the Advancement of Science 2020
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556837/
https://ncbi.nlm.nih.gov/pubmed/33055157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb5202
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