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An NF-κB–driven lncRNA orchestrates colitis and circadian clock
We uncover a cycling and NF-κB–driven lncRNA (named Lnc-UC) that epigenetically modifies transcription of circadian clock gene Rev-erbα, thereby linking circadian clock to colitis. Cycling expression of Lnc-UC is generated by the central clock protein Bmal1 via an E-box element. NF-κB activation in...
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| 出版年: | Sci Adv |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Association for the Advancement of Science
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7556837/ https://ncbi.nlm.nih.gov/pubmed/33055157 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb5202 |
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