The Phosphodiesterase Type 5 Inhibitor Sildenafil Improves DNA Stability and Redox Homeostasis in Systemic Sclerosis Fibroblasts Exposed to Reactive Oxygen Species

Systemic sclerosis (SSc) is a multi-system connective tissue disease characterized by the increased deposition of extracellular matrix proteins such as collagen and fibronectin. Although the pathogenesis is not completely understood, a number of studies suggest that free radicals could be the major...

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Publicado en:Antioxidants (Basel)
Autores principales: Di Luigi, Luigi, Duranti, Guglielmo, Antonioni, Ambra, Sgrò, Paolo, Ceci, Roberta, Crescioli, Clara, Sabatini, Stefania, Lenzi, Andrea, Caporossi, Daniela, Del Galdo, Francesco, Dimauro, Ivan, Antinozzi, Cristina
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555932/
https://ncbi.nlm.nih.gov/pubmed/32854347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9090786
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