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Implications of the Orb2 Amyloid Structure in Huntington’s Disease
Huntington’s disease is a progressive, autosomal dominant, neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. As a result, the translated protein, huntingtin, contains an abnormally long polyglutamine stretch that makes it prone to misfold and aggregating. Aggregatio...
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| Udgivet i: | Int J Mol Sci |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7555547/ https://ncbi.nlm.nih.gov/pubmed/32967102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186910 |
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