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Molecular Modeling of Pathogenic Mutations in the Keratin 1B Domain

Keratin intermediate filaments constitute the primary cytoskeletal component of epithelial cells. Numerous human disease phenotypes related to keratin mutation remain mechanistically elusive. Our recent crystal structures of the helix 1B heterotetramer from keratin 1/10 enabled further investigation...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Hinbest, Alexander J., Eldirany, Sherif A., Ho, Minh, Bunick, Christopher G.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555247/
https://ncbi.nlm.nih.gov/pubmed/32927888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186641
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