The Sd(a) Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition

Background: The Sd(a) antigen and its biosynthetic enzyme B4GALNT2 are highly expressed in healthy colon but undergo a variable down-regulation in colon cancer. The biosynthesis of the malignancy-associated sialyl Lewis x (sLe(x)) antigen in normal and cancerous colon is mediated by fucosyltransfera...

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Udgivet i:Int J Mol Sci
Main Authors: Pucci, Michela, Gomes Ferreira, Inês, Malagolini, Nadia, Ferracin, Manuela, Dall’Olio, Fabio
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555213/
https://ncbi.nlm.nih.gov/pubmed/32911675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186558
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