Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule—Purkinje Neuron Synaptic Strength

Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca(2+)) homeostasis after stimuli. Cerebellar ataxias and corticospinal motor neuron degeneration are determined by...

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Publicado en:Int J Mol Sci
Autores principales: Arsović, Aleksandar, Halbach, Melanie Vanessa, Canet-Pons, Júlia, Esen-Sehir, Dilhan, Döring, Claudia, Freudenberg, Florian, Czechowska, Nicoletta, Seidel, Kay, Baader, Stephan L., Gispert, Suzana, Sen, Nesli-Ece, Auburger, Georg
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7555182/
https://ncbi.nlm.nih.gov/pubmed/32932600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186673
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