Connexin Hemichannel Mimetic Peptide Attenuates Cortical Interneuron Loss and Perineuronal Net Disruption Following Cerebral Ischemia in Near-Term Fetal Sheep

Perinatal hypoxia-ischemia is associated with disruption of cortical gamma-aminobutyric acid (GABA)ergic interneurons and their surrounding perineuronal nets, which may contribute to persisting neurological deficits. Blockade of connexin43 hemichannels using a mimetic peptide can alleviate seizures...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Yang, Panzao, Davidson, Joanne O., Fowke, Tania M., Galinsky, Robert, Wassink, Guido, Karunasinghe, Rashika N., Prasad, Jaya D., Ranasinghe, Sumudu, Green, Colin R., Bennet, Laura, Gunn, Alistair J., Dean, Justin M.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554896/
https://ncbi.nlm.nih.gov/pubmed/32899855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21186475
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