Uncoupling Therapeutic Efficacy from Immune-Related Adverse Events in Immune Checkpoint Blockade

Immunotherapy with monoclonal antibodies targeting immune checkpoint molecules, including programmed death-1 (PD-1), PD ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated antigen (CTLA)-4, has become prominent in the treatment of many types of cancer. However, a significant number of patients t...

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Bibliografiske detaljer
Udgivet i:iScience
Main Authors: Hu, Weilei, Wang, Guosheng, Wang, Yian, Riese, Matthew J., You, Ming
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7554032/
https://ncbi.nlm.nih.gov/pubmed/33083746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101580
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