Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer

BACKGROUND: Mutations of the tumour-suppressor gene TP53 are the most frequent somatic genomic alterations in head and neck squamous cell carcinoma (HNSCC). However, it is not yet clear whether specific TP53 mutations bear distinct clinical and pathophysiological significance in different HNSCC subg...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Caponio, Vito Carlo Alberto, Troiano, Giuseppe, Adipietro, Iolanda, Zhurakivska, Khrystyna, Arena, Claudia, Mangieri, Domenica, Mascitti, Marco, Cirillo, Nicola, Lo Muzio, Lorenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553957/
https://ncbi.nlm.nih.gov/pubmed/32684626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0984-6
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