Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer

BACKGROUND: Mutations of the tumour-suppressor gene TP53 are the most frequent somatic genomic alterations in head and neck squamous cell carcinoma (HNSCC). However, it is not yet clear whether specific TP53 mutations bear distinct clinical and pathophysiological significance in different HNSCC subg...

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Опубликовано в: :Br J Cancer
Главные авторы: Caponio, Vito Carlo Alberto, Troiano, Giuseppe, Adipietro, Iolanda, Zhurakivska, Khrystyna, Arena, Claudia, Mangieri, Domenica, Mascitti, Marco, Cirillo, Nicola, Lo Muzio, Lorenzo
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553957/
https://ncbi.nlm.nih.gov/pubmed/32684626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0984-6
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