CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entire SARS-CoV-2 proteome and show kinetics of early differentiation

Characterization of the T cell response in individuals who recover from SARS-CoV-2 infection is critical to understanding its contribution to protective immunity. A multiplexed peptide-MHC tetramer approach was used to screen 408 SARS-CoV-2 candidate epitopes for CD8+ T cell recognition in a cross-s...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Kared, Hassen, Redd, Andrew D, Bloch, Evan M, Bonny, Tania S., Sumatoh, Hermi, Kairi, Faris, Carbajo, Daniel, Abel, Brian, Newell, Evan W, Bettinotti, Maria P., Benner, Sarah E., Patel, Eshan U., Littlefield, Kirsten, Laeyendecker, Oliver, Shoham, Shmuel, Sullivan, David, Casadevall, Arturo, Pekosz, Andrew, Nardin, Alessandra, Fehlings, Michael, Tobian, Aaron AR, Quinn, Thomas C
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7553170/
https://ncbi.nlm.nih.gov/pubmed/33052343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.08.330688
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