Clostridial C3 Toxins Enter and Intoxicate Human Dendritic Cells

C3 protein toxins produced by Clostridium (C.) botulinum and C. limosum are mono-ADP-ribosyltransferases, which specifically modify the GTPases Rho A/B/C in the cytosol of monocytic cells, thereby inhibiting Rho-mediated signal transduction in monocytes, macrophages, and osteoclasts. C3 toxins are s...

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Bibliografische gegevens
Gepubliceerd in:Toxins (Basel)
Hoofdauteurs: Fellermann, Maximilian, Huchler, Christina, Fechter, Lea, Kolb, Tobias, Wondany, Fanny, Mayer, Daniel, Michaelis, Jens, Stenger, Steffen, Mellert, Kevin, Möller, Peter, Barth, Thomas F. E., Fischer, Stephan, Barth, Holger
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7551598/
https://ncbi.nlm.nih.gov/pubmed/32883045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins12090563
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