Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis

Venezuelan equine encephalitis virus (VEEV), a mosquito transmitted alphavirus of the Togaviridae family, can cause a highly inflammatory and encephalitic disease upon infection. Although a category B select agent, no FDA-approved vaccines or therapeutics against VEEV currently exist. We previously...

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Vydáno v:Viruses
Hlavní autoři: Bakovic, Allison, Bhalla, Nishank, Kortchak, Stephanie, Sun, Chengqun, Zhou, Weidong, Ahmed, Aslaa, Risner, Kenneth, Klimstra, William B., Narayanan, Aarthi
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7551587/
https://ncbi.nlm.nih.gov/pubmed/32933112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12091021
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