Binding Sites of Anti-Lcr V Monoclonal Antibodies Are More Critical than the Avidities and Affinities for Passive Protection against Yersinia pestis Infection in a Bubonic Plague Model

Plague is a zoonotic disease that is caused by Yersinia pestis. Monoclonal antibodies (mAbs) that bind to the V-antigen, a virulence factor that is produced by Y. pestis, can passively protect mice from plague. An analysis of protective mAbs that bind to V-antigen was made to assess binding sites, a...

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Publicado en:Antibodies (Basel)
Main Authors: Amemiya, Kei, Dankmeyer, Jennifer L., Keasey, Sarah L., Trevino, Sylvia R., Wormald, Michael M., Halasohoris, Stephanie A., Ribot, Wilson J., Fetterer, David P., Cote, Christopher K., Worsham, Patricia L., Adamovicz, Jeffrey J., Ulrich, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7551159/
https://ncbi.nlm.nih.gov/pubmed/32756297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antib9030037
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