CASCADE: a phase 2, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of tezepelumab on airway inflammation in patients with uncontrolled asthma

BACKGROUND: Patients with severe, uncontrolled asthma, particularly those with a non-eosinophilic phenotype, have a great unmet need for new treatments that act on a broad range of inflammatory pathways in the airway. Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stro...

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Bibliographische Detailangaben
Veröffentlicht in:Respir Res
Hauptverfasser: Emson, Claire, Diver, Sarah, Chachi, Latifa, Megally, Ayman, Small, Cherrie, Downie, John, Parnes, Jane R., Bowen, Karin, Colice, Gene, Brightling, Chris E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Study Protocol
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550845/
https://ncbi.nlm.nih.gov/pubmed/33050900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-020-01513-x
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