MKI-1, a Novel Small-Molecule Inhibitor of MASTL, Exerts Antitumor and Radiosensitizer Activities Through PP2A Activation in Breast Cancer

Although MASTL (microtubule-associated serine/threonine kinase-like) is an attractive target for anticancer treatment, MASTL inhibitors with antitumor activity have not yet been reported. In this study, we have presented a novel MASTL inhibitor, MKI-1, identified through in silico screening and in v...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Kim, Ah-Young, Yoon, Yi Na, Leem, Jiyeon, Lee, Jee-Young, Jung, Kwan-Young, Kang, Minsung, Ahn, Jiyeon, Hwang, Sang-Gu, Oh, Jeong Su, Kim, Jae-Sung
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7550800/
https://ncbi.nlm.nih.gov/pubmed/33117702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.571601
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