Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas

Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours with a hereditary background in over one-third of patients. Mutations in succinate dehydrogenase (SDH) genes increase the risk for PPGLs and several other tumours. Mutations in subunit B (SDHB) in particular are a risk fac...

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Publicado en:J Pathol
Autores principales: Wallace, Paal W, Conrad, Catleen, Brückmann, Sascha, Pang, Ying, Caleiras, Eduardo, Murakami, Masanori, Korpershoek, Esther, Zhuang, Zhengping, Rapizzi, Elena, Kroiss, Matthias, Gudziol, Volker, Timmers, Henri JLM, Mannelli, Massimo, Pietzsch, Jens, Beuschlein, Felix, Pacak, Karel, Robledo, Mercedes, Klink, Barbara, Peitzsch, Mirko, Gill, Anthony J, Tischler, Arthur S, de Krijger, Ronald R, Papathomas, Thomas, Aust, Daniela, Eisenhofer, Graeme, Richter, Susan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7548960/
https://ncbi.nlm.nih.gov/pubmed/32462735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5472
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