Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides

[Image: see text] Naturally occurring membranolytic antimicrobial peptides (AMPs) are rarely cell-type selective and highly potent at the same time. Template-based peptide design can be used to generate AMPs with improved properties de novo. Following this approach, 18 linear peptides were obtained...

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Gepubliceerd in:Biochemistry
Hoofdauteurs: Müller, Alex T., Posselt, Gernot, Gabernet, Gisela, Neuhaus, Claudia, Bachler, Simon, Blatter, Markus, Pfeiffer, Bernhard, Hiss, Jan A., Dittrich, Petra S., Altmann, Karl-Heinz, Wessler, Silja, Schneider, Gisbert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2020
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547863/
https://ncbi.nlm.nih.gov/pubmed/32936629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00565
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