Molecular dynamics of the histamine H3 membrane receptor reveals different mechanisms of GPCR signal transduction

In this work, we studied the mechanisms of classical activation and inactivation of signal transduction by the histamine H3 receptor, a 7-helix transmembrane bundle G-Protein Coupled Receptor through long-time-scale atomistic molecular dynamics simulations of the receptor embedded in a hydrated doub...

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Publicat a:Sci Rep
Autors principals: Herrera-Zúñiga, Leonardo David, Moreno-Vargas, Liliana Marisol, Ballaud, Luck, Correa-Basurto, José, Prada-Gracia, Diego, Pastré, David, Curmi, Patrick A., Arrang, Jean Michel, Maroun, Rachid C.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547658/
https://ncbi.nlm.nih.gov/pubmed/33037273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73483-5
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