Response to abatacept is associated with the inhibition of proteasome β1i expression in T cells of patients with rheumatoid arthritis

OBJECTIVE: Abatacept is a biological disease-modifying antirheumatic drug (DMARD) used for the treatment of rheumatoid arthritis (RA) and modulates the costimulatory signal by cluster of differentiation (CD)28:CD80/CD86 interaction required for T cell activation. Since CD28-mediated signalling regul...

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Bibliografische gegevens
Gepubliceerd in:RMD Open
Hoofdauteurs: Ghannam, Khetam, Martinez Gamboa, Lorena, Kedor, Claudia, Spengler, Lydia, Kuckelkorn, Ulrike, Häupl, Thomas, Burmester, Gerd, Feist, Eugen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BMJ Publishing Group 2020
Onderwerpen:
Rheumatoid Arthritis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547540/
https://ncbi.nlm.nih.gov/pubmed/32998980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/rmdopen-2020-001248
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